Melano TX Ultra – Tranexamic Acid + Azelaic Acid Cream for Melasma & Dark Spots (15g)

An advanced pigmentation-correcting cream combining tranexamic acid, azelaic acid and niacinamide to target melasma, stubborn dark spots and uneven tone.

Best for: melasma, post-acne marks, and resistant pigmentation that hasn't responded to basic brightening products.

How to use: apply a thin layer to affected areas at night, or as directed by your dermatologist. Always pair with a broad-spectrum SPF 50 in the daytime — pigmentation treatment without sun protection will not hold.

Texture: lightweight cream for targeted use on pigmented areas.

Key ingredients: tranexamic acid, azelaic acid, niacinamide.

Size: 15g.

This is a prescription-grade formulation and is best used under a dermatologist's guidance. Patch test before first use and introduce gradually.

Not sure if this suits your pigmentation type? Book a ₹299 online dermatologist video consult at Skn Biome.

Nicotinoyl Dipeptide-22, Tranexamoyl Dipeptide-22, Lemon Peel Ferment Extract, Orange Peel Extract, Caprylic Capric Triglyceride, Glyceryl Stearate, Kojic Acid Dipalmitate, Niacinamide, Mulberry Extract, Pea Seed Extract

FAQs

Q1. What are Nicotinoyl Dipeptide-22 and Tranexamoyl Dipeptide-22, and why are they used instead of plain Niacinamide and Tranexamic Acid?
A1. Melano TX Ultra Cream uses next-generation peptide conjugates rather than free-form actives. Nicotinoyl Dipeptide-22 is Niacinamide chemically bonded to a dipeptide carrier, which significantly improves its stability against thermal and light-induced degradation and enhances its penetration through peptide transporter pathways in the epidermis. Tranexamoyl Dipeptide-22 applies the same principle to Tranexamic Acid. Both peptide conjugate formats ensure more consistent, potent delivery than the free-molecule versions used in most brightening formulations — working more efficiently at lower concentrations and with greater stability across the product's shelf life.

Q2. How do the two peptide complexes in Melano TX Ultra Cream attack hyperpigmentation?
A2. The two complexes interrupt melanogenesis at distinct stages of the pigmentation cascade. Tranexamoyl Dipeptide-22 inhibits the plasmin-mediated UV signalling that stimulates melanocytes — reducing the upstream trigger for new melanin production. Nicotinoyl Dipeptide-22 then blocks melanosome transfer from melanocytes to surrounding keratinocytes — preventing melanin that is produced from being deposited into the visible layers of skin. This upstream-to-downstream tandem is significantly more effective than targeting either step alone, and both mechanisms are distinct from hydroquinone, making Melano TX Ultra Cream suitable for long-term use.

Q3. Who is Melano TX Ultra Cream most appropriate for?
A3. Melano TX Ultra Cream is designed for adults with melasma, PIH from acne or sun damage, generalised uneven skin tone, or stubborn dark spots — particularly relevant for Fitzpatrick III–VI South Asian skin, where multiple forms of hyperpigmentation frequently coexist and standard tyrosinase inhibitors alone often produce incomplete results. Unlike hydroquinone-based treatments which carry risks with prolonged use on darker skin tones, Melano TX Ultra Cream uses signalling-level and transfer-level mechanisms that do not affect normal melanocyte function.

Q4. What role do the Lemon Peel Ferment and Orange Peel Extracts play in the formula?
A4. Lemon and Orange Peel Ferment Extracts deliver natural flavonoids (hesperidin, naringenin) and Vitamin C precursors through a biofermentation process that improves their bioavailability and enzymatic activity compared to raw plant extracts. These fermented citrus extracts provide additional antioxidant protection, mild brightening via flavonoid inhibition of oxidative pigmentation pathways, and help buffer the skin's adaptation to the prescription-strength depigmenting actives — useful for reactive skin encountering an advanced brightening regimen for the first time.

Q5. How quickly does Melano TX Ultra Cream produce results, and is daily SPF required?
A5. Most users notice brighter overall tone and reduced spot intensity within four to six weeks of consistent use. Established melasma typically requires three to four months for full results. Daily broad-spectrum SPF 30 or above is clinically essential — UV exposure triggers the very plasmin-signalling and melanocyte stimulation that Tranexamoyl Dipeptide-22 is suppressing, making sun protection an integral part of the treatment protocol rather than an optional add-on. Physical SPF containing zinc oxide or titanium dioxide is preferred for melasma patients as it also blocks visible-light wavelengths.

Country of Origin: India
Mfg/Marketer details: Pharma Synth Formulations Ltd., Plot No. 18-22, Sector-6B, SIDCUL-IIE, Haridwar, Uttarakhand - 249401, India
Shelf Life: 24 months from manufacturing date
Storage: Store in a cool, dry place away from direct sunlight
Safety Information: For external use only. Avoid contact with eyes and mucous membranes. Discontinue use if irritation occurs. Keep out of reach of children.