ISIS Pharma Viti Skin Repigmentation Regulating Hydrogel

ISIS Pharma Vitiskin is a specialized dermo-cosmetic serum formulated to rebalance skin suffering from depigmentation, such as vitiligo. Enriched with antioxidants, trace elements, and hydrating actives, it helps fight oxidative stress, restore balance to melanocyte activity, and improve overall skin appearance. With a lightweight texture, it absorbs quickly and can be used alongside medical treatments for vitiligo as supportive skincare.

• Superoxide Dismutase – Powerful antioxidant enzyme
• Copper & Zinc – Essential trace elements that rebalance skin metabolism
• Calcium Pantothenate – Aids in skin repair
• Vitamin B12 – Supports skin health & cellular activity
• Glycerin – Hydrates and soothes skin

FAQs

Q1. What is the scientific rationale for using Superoxide Dismutase in a vitiligo product like ISIS Pharma Viti Skin?
A1. Current leading research on vitiligo identifies oxidative stress — specifically elevated hydrogen peroxide (H2O2) in skin — as a key driver of melanocyte damage and loss at depigmented patches. Superoxide Dismutase (SOD) is an endogenous antioxidant enzyme that catalyses the breakdown of superoxide radicals to hydrogen peroxide and water, reducing overall reactive oxygen species (ROS) at the skin level. In vitiligo skin where the antioxidant defense system is compromised, topical SOD helps restore the biochemical environment melanocytes need to survive and repigment. This mechanism is why antioxidant therapy is increasingly part of integrative vitiligo management.

Q2. Why does Viti Skin Repigmentation Hydrogel contain Copper and Zinc?
A2. Copper is an essential cofactor for tyrosinase — the enzyme responsible for melanin synthesis in melanocytes. In vitiligo, dysfunctional or absent melanocytes cannot produce melanin regardless of tyrosinase activation. Copper in the formula supports the enzyme's activity in residual and recovering melanocytes at the borders of depigmented patches (where repigmentation typically begins). Zinc PCA plays a complementary role in regulating melanocyte metabolism and has anti-inflammatory properties that protect regenerating melanocytes from further oxidative damage during the repigmentation process.

Q3. Can ISIS Pharma Viti Skin work independently as a standalone vitiligo treatment?
A3. Viti Skin is a supportive skincare product, not a medical treatment for vitiligo. The most effective vitiligo management combines medical interventions (narrowband UVB phototherapy, topical calcineurin inhibitors, topical corticosteroids, or systemic therapies for extensive vitiligo) with supportive skincare. Viti Skin is designed to complement these therapies by addressing the oxidative stress and trace mineral deficiencies that impair natural repigmentation. It should be used under a dermatologist's guidance alongside, not instead of, appropriate medical treatment.

Q4. How long does it take to see repigmentation with ISIS Pharma Viti Skin?
A4. Repigmentation in vitiligo is inherently slow — even with phototherapy (the most effective current treatment), meaningful repigmentation typically takes 3–6 months of treatment. With Viti Skin as a supportive product, visible improvement may begin within 2–3 months of consistent use alongside medical therapy. Results vary significantly depending on vitiligo type (segmental vs. non-segmental), location of patches (face responds better than extremities), duration of the condition, and what medical treatment is being used concurrently. Consistent application twice daily without interruption is important for any response to become visible.

Q5. Is strict sunscreen use required for depigmented skin while using Viti Skin?
A5. Yes — strictly necessary. Depigmented skin completely lacks melanin and has essentially zero natural UV protection. Sun exposure on vitiligo patches causes rapid and severe burning at doses that would only tan or mildly pink normal skin. Additionally, UV exposure triggers the oxidative stress (H2O2 accumulation) that contributes to ongoing melanocyte damage. Daily broad-spectrum SPF 50+ on depigmented areas is essential to protect regenerating melanocytes during repigmentation treatment and to prevent burning and photoageing of the affected skin.

Country of Origin: France
Mfg/Marketer details: Isispharma France, Avenue De La Marne, Parc-Des Chenes, 59290 Wasquehal, France
Importer details: Iberia Skinbrands India Pvt. Ltd., Plot No. 1, Pocket C-8, Sector 17, Dwarka, Delhi - 110078, India
Shelf Life: 36 months from manufacturing date
Storage: Store in a cool, dry place away from direct sunlight
Safety Information: For external use only. Avoid contact with eyes. If irritation occurs, discontinue use and consult a dermatologist.